• The expression and localization of

  2021-11-08

  

  The expression and localization of Cx43, Cx46 and Cx50 in the anterior pituitary vary with physiological activities and with various conditions associated with both natural and pathological changes in hormone secretion. Anterior pituitary Cx43 and Cx50 levels increase and exhibit a more widespread d

• Primarily because secretase was a therapeutic target

  2021-11-08

  

  Primarily because γ-secretase was a therapeutic target in AD, a plethora of γ-secretase inhibitors (GSIs) have been developed that effectively inhibit γ-secretase cleavage in humans [16]. Indeed, “druggability” of γ-secretase has not been an issue even when the identity of the target was unknown in

• G quadruplex DNA structures may

  2021-11-08

  

  G-quadruplex DNA structures may exist in either positive or negative strand of a promoter to regulate gene expression. The positive strand of the HOXC10 promoter is overall C-rich in the 1000 bp upstream of the TSS (36.6% of C versus 24.1% of G) and contains many C-runs; thus, G-quadruplex structure

• One year after the Brose paper was published

  2021-11-08

  

  One year after the Brose . paper was published, Littleton . reported the first measurements of evoked synaptic transmission in syt1 nulls, using the neuromuscular junction as a model system. These experiments revealed that syt1 was essential for rapid, robust evoked neurotransmitter release. Simil

• SCH is a H R receptor antagonist introduced

  2021-11-08

  

  SCH-497079 is a H3R receptor antagonist introduced by Schering-Plough, without any publicized pharmacological and structural information. A Phase II clinical trial assessment of SCH-497079 on weight has been completed in a multicenter, randomized, parallel-group and placebo-controlled study in obese

• Several mechanisms have been suggested to underline the rele

  2021-11-08

  

  Several mechanisms have been suggested to underline the release of signalling molecules from astrocytes: reverse operation of glutamate transporters, volume-regulated anion channels, gap-junctional hemi channels, diffusional release through purinergic receptors and Ca2+-dependent exocytosis [2], [15

• br Endogenous and synthetic ligands of GPR

  2021-11-06

  

  Endogenous and synthetic ligands of GPR55 There are currently limited commercially available synthetic agonists and antagonists that are specific for GPR55. A large number of studies have investigated the pharmacology of GPR55 4, 23, 25, 30, 31, 32, 33, 34, 35, with contradictory findings reporte

• Miglitol br Materials and methods br Results br Discussion

  2021-11-06

  

  Materials and methods Results Discussion Until very recently, the anti-atherogenic activity of niacin was attributed almost exclusively to its impact on HDL and other plasma lipids, perhaps mediated via its action on GPR109A expressed in adipose or other tissues. However, recent clinical st

• br Discussion Our findings indicated that starting

  2021-11-06

  

  Discussion Our findings indicated that starting ART for asymptomatic HIV-infected pregnant women before their CD4 count falls below 500cells/mm3 is beneficial for CD4 normalization (CD4 recovery to 750cells/mm3 or more) in resource-limited settings. Women who started ART at lower baseline CD4 cou

• Through the analysis of various

  2021-11-06

  

  Through the analysis of various synthetic GPR40 agonists as reported in literature, we found that a number of these compounds contained a phenylpropanoic 4SC-202 sale motif which was inspired from naturally occurring medium to long chain fatty acids. For instance, in the early period of discovering

• br Acknowledgements This work was financed by

  2021-11-06

  

  Acknowledgements This work was financed by the projects “Mejora Genética del Almendro” (MINECO-Spain, AGL2017-85042-R), “The molecular mechanisms to break flower bud dormancy in fruit trees” to RS-P within the Villum Young Investigator Program and by the VILLUM Research Center for Plant Plasticit

• GLP and glucose dependent insulinotropic peptide GIP

  2021-11-06

  

  GLP-1 and glucose-dependent insulinotropic peptide (GIP) are gut hormones secreted from intestinal L Wnt agonist 1 receptor and K cells, respectively. Together, these hormones account for the vast majority of the incretin effect, the enhanced postprandial insulin secretion observed in healthy adult

• It is important to underline that although

  2021-11-06

  

  It is important to underline that IL-4, murine recombinant sale although ghrelin increases the motivation to eat even in fed state, its effects on food intake and reward are blunted in obese animal models (Zigman et al., 2016). This emphasizes also the interconnection between homeostatic regulation

• Polyunsaturated fatty acids PUFAs represent a class of lipid

  2021-11-06

  

  Polyunsaturated fatty acids (PUFAs) represent a class of lipids that contain two or more carbon double (unsaturated) bonds (CC) and classified as n-3, n-6 and n-9 fatty acids. PUFAs including n-3 such as docosahexaenoic x gal (DHA), eicosapentaenoic acid (EPA) and n-6 such as arachidonic acid (AA)

• The improved glucose tolerance of Ffar R W R

  2021-11-06

  

  The improved glucose tolerance of Ffar1R258W/R258W mice on HFD was unexpected. In combination with similar fasting blood glucose levels, the significant lower fasting plasma insulin of mutant mice compared to wild-type mice is indicative of improved insulin sensitivity. However, peripheral insulin r

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