• br Acknowledgments We apologize to

  2022-03-14

  

  Acknowledgments We apologize to the researchers who were not referenced due to space limitations. We thank Dave Primm (Department of Surgery, University of Texas Southwestern Medical Center) for his critical reading of the manuscript. This work was supported by grants from the US National Institu

• pyruvate dehydrogenase kinase inhibitor Introduction Vesicul

  2022-03-14

  

  Introduction Vesicular exocytosis, an intracellular membrane trafficking pathway, is a ubiquitous process for intercellular communication. It occurs when an intracellular vesicle fuses with the cell membrane and subsequently releases an infinitely minute number of chemical or biochemical messengers

• The importance of the histone chaperone function of Hat

  2022-03-14

  

  The importance of the histone chaperone function of Hat1p was highlighted by the recent demonstration that the catalytic activity of Hat1p is not sufficient for its function in vivo. Fusion of a nuclear export signal (NES) to yeast Hat1p effectively excluded the enzyme from the nucleus, with a conco

• Aberrant expression of HKII may be a required feature for

  2022-03-14

  

  Aberrant expression of HKII may be a required feature for cancer development and progression. Overexpression of HKII has been reported in tumor tissues of cancer patients with liver [9], ovary [8], [24] and larynx [25]. The clinical significance of HKII in cancer was noted as overexpression of HKII

• Finally worth of mention are few papers that report on

  2022-03-14

  

  Finally, worth of mention are few papers that report on the discovery of HO-2 selective inhibitors. In 2013, starting from the screening of a Ezetimibe library, the above-mentioned Canadian research group identified Clemizole (Table 6) as a new hit compound for the development of the first series o

• Interestingly myorelaxation and the stimulation of cGMP prod

  2022-03-14

  

  Interestingly, myorelaxation and the stimulation of cGMP production are properties also reported for sGC stimulators, such as YC-1 and BAY 41–2272 (i.e., indazole compounds that were discovered in the 1990s) [35]. They relax aortic ring contractions induced by phenylephrine, and their effects are si

• br Conflict of interest br Acknowledgements

  2022-03-14

  

  Conflict of interest Acknowledgements A Class of Unconventional, Dimerization-Activated GTPases GTP-binding proteins, or GTPases, are a superfamily of proteins that regulate numerous cellular pathways 1, 2, 3, 4. Pioneering work on the extended Ras subfamily of GTPases, exemplified by Ras,

• The biological activity at GPR a

  2022-03-12

  

  The biological activity at GPR109a of each of the 4-functionalized-5-alkyl-pyrazole-3-carboxylic acids (–) was measured using a cAMP whole cell Dynamic2 Homogenous Time-Resolved Fluorescence (HTRF) assay (). Twelve compounds were found to exhibit an EC below 1μM, and of these seven exhibited EC valu

• Due to the therapeutic potential of GlyT inhibitors numerous

  2022-03-12

  

  Due to the therapeutic potential of GlyT1 inhibitors, numerous drug screening campaigns have been started - and are still going on - which aimed at the identification of compounds with biological activity at or affinity for this drug target. For characterization of biological activity at GlyT1, tran

• br Experimental procedures br Results br Discussion Although

  2022-03-12

  

  Experimental procedures Results Discussion Although the presence and localization of the GlyR subunits have been determined in the adult retina, the proportion of each GlyR subunit has not been assessed in the adult or in the developing retina. In the present study, we carried out the absol

• The general synthetic routes leading to aspartate

  2022-03-12

  

  The general synthetic routes, leading to aspartate and 2,3-diaminopropionate analogs, are shown in . As outlined in , aspartic Cy3-UTP synthesis analogs – were synthesized through standard carbodiimide-mediated coupling between an amine and an appropriately protected aspartic acid. It is worth menti

• In contrast to short term effects long term exposure of

  2022-03-12

  

  In contrast to short-term effects, long-term exposure of beta cells to FFAs impairs insulin secretion and triggers apoptosis [13]. The deleterious effects of FFAs have been linked to altered glucose/fatty AP26113 oxidation cycle [13], decreased NADPH content [14], endoplasmic reticulum (ER) stress

• br Role of ghrelin in reward and addiction In

  2022-03-12

  

  Role of ghrelin in reward and addiction In addition to its well-known effects on RG2833 australia homeostasis regulation at the hypothalamic level [reviews in (Al Massadi et al., 2017, Muller et al., 2015)], ghrelin also has the ability to increase food motivation acting on hypothalamic and extr

• br Discussion According to the

  2022-03-12

  

  Discussion According to the generally accepted notion which originated from the study of ATP-depleted ion channels the changes in Ca2+ homeostasis induced by ATP depletion and leading to the activation of the Gárdos effect are due to the inhibition of Ca2+ pumping, and the subsequent entry of Ca

• IAA-94 receptor As many of the above studies highlight sever

  2022-03-12

  

  As many of the above studies highlight, several decades of research on Cx43 has revealed that many of these functional roles are attributed to the C-terminal domain (CT) of this protein which cannot be explained by the formation and existence of intercellular channels. Recent findings on the existen

16089 records 496/1073 page Previous Next First page 上5页 496497498499500 下5页 Last page