• The patient was consented to treatment on clinical trial NCT

  2019-04-16

  

  The patient was consented to treatment on clinical trial NCT02527447 and received treatment with salvage chemotherapy of mitoxantrone 12mg/m2/day IV on days 1–3, etoposide 200mg/m2/day continuous IV infusion (CIV) on days 8–10, and cytarabine 500mg/m2/day CIV on days 1–3 and 8–10 (EMA). Infectious

• br Discussion The site of

  2019-04-16

  

  Discussion The site of the successful ablation was the earliest site where a TSP was recorded during tachycardia. The TSP preceded each His bundle deflection by 15ms during tachycardia, but was inverted during atrial pacing. Moreover, the TSP–His deflection interval remained unchanged at differen

• lactacystin The pathophysiology underlying ONJ is unclear De

  2019-04-16

  

  The pathophysiology underlying ONJ is unclear. Decreased bone remodeling induced by bisphosphonates or inhibition of osteoclast function, which interferes with healing of the microfractures and trauma occurring after dental extraction, have been hypothesized as potential mechanisms for ONJ, but thes

• In the past decade preclinical studies have addressed the pu

  2019-04-16

  

  In the past decade, preclinical studies have addressed the putative role of non-coding RNAs in tumorigenesis, metastasis and therapy response in osteotropic cancers. Besides long non-coding RNAs, microRNAs (miRs) represent a class of small non-coding RNAs, (18–25 nucleotides long), that regulate pro

• br Treatment and follow up recommendations for patients rece

  2019-04-16

  

  Treatment and follow-up recommendations for patients receiving aromatase inhibitors Conclusions and future directions It is evident that, in addition to BMD, clinical risk factors can greatly influence fracture risk. In addition to morbidity and mortality, fractures are associated with high he

• Elacridar br Commentary Careful analysis of the electrocardi

  2019-04-16

  

  Commentary Careful analysis of the electrocardiograph (Fig. 1) reveals narrow and similar QRS complexes in all the beats, showing that they are all intrinsic QRS complexes. Some intrinsic P waves are also visible at the ST-T segment (after R3, R7, R11, and R15); these are the beats without any sp

• br The past decade has

  2019-04-16

  

  The past decade has seen increasing global policy attention to nutrition. Concrete steps have been taken to construct a global governance architecture for nutrition and also to mobilise resources for action. Efficacious, low-cost interventions exist, and there is greater consensus around technical

• In addition we are continuing our

  2019-04-16

  

  In addition, we are continuing our regular editorial policies of commissioning more specialised Clinical Reviews and Series across Group to provide a more focused and in-depth assessment for key diseases. And beyond providing knowledge and information, we want to encourage academic and practising c

• We also demonstrated by ELISA

  2019-04-15

  

  We also demonstrated by ELISA, ELISPOT and CTL assays the capacity of alum to induce a Th1 immune response. The evaluation of the sphk response against LALF32-51 peptide, E7 protein and LALF32-51-E7 fusion protein in immunized mice suggest that the antibodies response generated by the immunization i

• Introduction Personalized medicine is the major goal of tran

  2019-04-15

  

  Introduction Personalized medicine is the major goal of translational research in the post-genomic era. Numerous biomarkers have been identified by genomic or proteomic approach that can reclassify the disease glucokinase and predict clinical outcome. However, to define a specific disease phenotyp

• br Discussion Treatment of patients with vaginal

  2019-04-15

  

  Discussion Treatment of patients with vaginal leiomyosarcoma is challenging because of the rarity of this disease and a lack of controlled clinical trials comparing management strategies. At this time primary surgery remains the mainstay of management of vaginal leiomyosarcoma. Treatment plans sh

• br Postoperative rehabilitation Although surgery is the main

  2019-04-15

  

  Postoperative rehabilitation Although surgery is the main curative therapy for lung cancer, the procedure can directly cause a reduction in pulmonary functional reserve and exercise capacity proportional to the extent of resection. The problems might be more severe in those undergoing multimodali

• br Consideracj es fin is

  2019-04-15

  

  Consideracjóes fináis De acordo com as evidências coletadas com tsa inhibitor pesquisa, algumas discussões passam a ser sugeridas. Inicialmente, das parcerias entre Estado e sociedade foram abertas vagas na saúde públicas a serem ocupadas por “pessoas jurídicas de direito privados”, e mesmo sem f

• Whole body CT only showed mild splenomegaly cm and

  2019-04-15

  

  Whole-body CT only showed mild splenomegaly (14cm) and an enlarged iliac lymph node (1.5×3cm). Cranial MR yielded no specific findings. In the meantime, the patient was given Rituximab. He received 375mg/m2 of Rituximab per week, but after the third dose the patient rapidly developed shock and abdo

• 17-aag The extraction of primary teeth has shown a

  2019-04-15

  

  The extraction of primary teeth has shown a significant upward trend since 2011, and after 2012, these numbers showed a significant difference compared with 2006. One possible explanation for this 17-aag was the high failure rate of upper anterior composite resin strip crowns placed over teeth afte

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