• Dlin-MC3-DMA: Unveiling Ionizable Lipid Design for Precis...

  2025-09-26

  Explore the molecular engineering and predictive design of Dlin-MC3-DMA, a leading ionizable cationic liposome for advanced lipid nanoparticle siRNA delivery. This article uniquely connects machine learning insights with structural-function relationships to guide next-generation mRNA and siRNA therapeutic development.

• 5-Ethynyl-2'-deoxyuridine (5-EdU): Unraveling Neurogeneti...

  2025-09-25

  Explore how 5-Ethynyl-2'-deoxyuridine (5-EdU) enables high-resolution neurogenetic mapping and advanced click chemistry cell proliferation detection. This article offers a unique synthesis of developmental neuroscience and assay innovation, grounded in recent landmark research.

• ARCA EGFP mRNA (5-moUTP): Advanced Mechanistic Insights a...

  2025-09-24

  Explore the unique molecular mechanisms and translational impact of ARCA EGFP mRNA (5-moUTP) as a direct-detection reporter mRNA for fluorescence-based transfection control. This article reveals deeper scientific insights and comparative perspectives not found in existing resources.

• Nitrocefin for β-Lactamase Detection: Applications in Met...

  2025-09-23

  Explore the unique role of Nitrocefin as a chromogenic cephalosporin substrate in colorimetric β-lactamase assays, with a focus on investigating metallo-β-lactamases and antibiotic resistance mechanisms in emerging pathogens.

• In addition to it we also showed that glycine increases

  2025-03-03

  

  In addition to it, we also showed that glycine increases miR-301a expression which directly binds to PTEN 3′UTR target sites [13]. Glycine confers neuroprotection through microRNA-301a/PTEN signaling in rats cortical neurons in oxygen deprivation model [13]. Substantial studies indicate that inhibit

• In the presence of detrimental conditions

  2025-03-03

  

  In the presence of detrimental conditions, such as inflammation, hypoxia, ischemia trauma or neoplastic milieu, the extracellular levels of adenosine increase massively, reaching micromolar range [51,52]. In these pathological contexts, adenosine accumulation stems from increased extracellular depho

• br Results and discussion The morphology and

  2025-03-03

  

  Results and discussion The morphology and structure of chembridge receptor samples were observed using an SEM, as shown in Fig. 1. The length and thickness of the actin filaments were regulated with ABPs to mimic the various actins observed in cells. We prepared three types of F-actin with or wit

• We have previously reported alterations of the

  2025-03-03

  

  We have previously reported alterations of the thymus in AChR-MG patients, especially in their germinal center Gel filtration column (defined as CD19+CD38+ cells by flow cytometric analysis). First, we found that, in MG thymi, this subset failed to show the normal down-regulation of Bcl-2, suggesti

• Our co IP data show that HT A or HT

  2025-03-03

  

  Our co-IP data show that 5HT1A or 5HT2A receptors do not heterodimerize with mGluR1α receptors. Given that both 5-HT and mGlu receptors are GPCRs and produce anxiolytic effects, a degree of cooperativity via a functional cross-talk may still exist between these receptors [11]. In addition to the fun

• Roles of Aurora kinases in directly activating multiple onco

  2025-03-03

  

  Roles of Aurora kinases in directly activating multiple oncogenic pathways and promoting proliferation as well as transformation have also been demonstrated. Aurora-A has been shown to up-regulate telomerase reverse transcriptase mRNA through c-myc [26]. The kinase was also implicated in activating

• IGF is an anabolic growth

  2025-03-01

  

  IGF1 is an anabolic growth factor that induces hypertrophy and blocks atrophy in skeletal muscle by activating the PI3K/AKT/mTOR pathway (Egerman and Glass, 2014). In addition to its anabolic and anti-catabolic effects, IGF1 stimulates fatty HG-10-102-01 (FA) uptake and glucose metabolism (Clemmons

• Thymoquinone TQ is the major

  2025-03-01

  

  Thymoquinone (TQ) is the major active menin derived from Nigella sativa (Woo et al., 2012). Recent animal studies support the potential of TQ for the treatment of a variety of inflammatory disorders like inflammatory bowel disease (IBD), RA, and osteoarthritis (OA) (Salem, 2005, Badr et al., 2011).

• The first objective of the present study was to investigate

  2025-03-01

  

  The first objective of the present study was to investigate the impact of ageing on arginase activity in tissues which exhibit age-related impairments in their function. The second objective was to determine whether l-arginine supplementation modulated the effect of ageing on arginase activity. The

• In our study S aureus activated the

  2025-03-01

  

  In our study, S. aureus activated the TLR signaling pathways of BMECs, thus inducing profibrogenic growth factor expression via NF-κB and AP-1. Since fibrosis is an important pathogenic process in both bovine and human mastitis, further studies on the molecular mechanisms of S. aureus infection are

• CAY10603 br Introduction Increased renin angiotensin system

  2025-03-01

  

  Introduction Increased renin-angiotensin system (RAS) activity and inflammation in cardiovascular-related regions of the central nervous system contribute to the overactivity of neurohumoral systems that promote volume retention, cardiac remodeling and serious cardiac arrhythmias in systolic hear

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